Orbelli

Complete Ingredient Profile

Ingredient Name & Common Synonyms

Primary Name: L-Threonine
Common Synonyms: Threonine, (2S,3R)-2-Amino-3-hydroxybutanoic acid, Thr, T (single-letter abbreviation)
Chemical Classification: Essential amino acid, Polar amino acid, Hydroxyl-containing amino acid
Molecular Formula: C₄H₉NO₃

Overview

Botanical Family: Found across multiple protein sources in the plant and animal kingdoms
Primary Origin: Animal proteins (meat, poultry, fish, dairy), legumes, nuts, seeds, whole grains
Extraction Method: Fermentation using bacterial cultures (primarily Escherichia coli) or isolation from protein hydrolysates
Molecular Structure: Four-carbon amino acid with a hydroxyl group at the beta position, creating two chiral centers
Appearance: White, crystalline, odorless powder with a slightly sweet taste

Benefits & Uses

For Women's Hormonal Health:

Protein Synthesis Support: The female reproductive system is strongly influenced by nutrition and energy balance, with adequate amino acid intake crucial for hormonal function
Collagen Formation: Essential for collagen synthesis, supporting reproductive tissue integrity and health
Immune Function: Supports immune system function, which is closely linked to hormonal balance
Metabolic Health: Nutritional inputs and metabolic health are integrated into the coordination of reproduction

Primary Health Benefits:

Essential Amino Acid Function: They play a vital role in the structure of our bones, muscles, and skin
Collagen & Elastin Production: Critical component for connective tissue formation
Immune System Support: Required for antibody production and immune cell function
Protein Structure: Necessary for proper protein folding and enzymatic function
Neurotransmitter Synthesis: Involved in glycine production, supporting nervous system health

Deficiency Symptoms:

When we don't eat enough foods high in these important compounds, we can experience deficiency symptoms like mood changes, irritability, confusion, and digestive problems

Mechanism of Action:

Protein Building Block: Incorporates into structural and functional proteins
Hydroxyl Group Function: Enables hydrogen bonding for protein stability
Glycine Conversion: Can be converted to glycine, supporting neurotransmitter balance
Serine Pathway: Involved in serine metabolism and one-carbon unit transfer

Safety & Warnings

General Safety Profile:

Threonine has most often been used by adults in doses of 1.5-2.5 grams by mouth three times daily for up to 8 weeks. A dose of up to 4 grams daily has been used for up to 12 months

Dosage Safety:

Safe Range: Threonine doses of up to 4 grams daily for up to 12 months are regarded as safe
Orbelli Dosage: 250mg per serving - well below therapeutic limits, ensuring excellent safety
Daily Intake: The recommended daily intake is approximately 1000mg. Orbelli provides 25% of the recommended intake
Clinical Safety: The objective of this study was to determine, in a randomized, double-blind, controlled clinical trial, the safety and tolerability of l-threonine

Potential Side Effects:

Some individuals experience minor side effects such as an upset stomach, headache, nausea, and skin rash

Important Warnings:

Pregnancy & Breastfeeding: Insufficient safety data - consult healthcare provider before use
ALS Patients: For those with ALS (amyotrophic lateral sclerosis), special medical supervision may be required
May cause mild throat irritation in some individuals - this is normal and typically resolves quickly
Amino Acid Balance: Should be taken as part of a balanced amino acid profile

Recommended Patch-Test Instructions:

Not applicable for oral supplements. For topical applications containing L-threonine, perform a 48-hour patch test on the inner forearm.

Formulation Tips

Physical Properties:

pH Range: 5.6-6.2 (slightly acidic in aqueous solution)
Solubility: Highly soluble in water (20.5g/100mL at 25°C), insoluble in ethanol
Stability: Stable under normal processing conditions, sensitive to strong acids/bases
Melting Point: 255-257°C (with decomposition)

Optimal Dosing:

Therapeutic Range: 1-4 grams daily for specific health benefits
Orbelli Formula: 250mg per serving (optimal maintenance dose for daily support)
Bioavailability: Good oral absorption, competes with other large neutral amino acids
Timing: Best absorbed on an empty stomach, but can be taken with food

Pairing Suggestions:

Synergistic with: Other essential amino acids (lysine, methionine), vitamin C, B-vitamins
Compatible with: All amino acids, vitamins, and minerals in formulation
Enhanced by: Taking with a complete amino acid profile for optimal protein synthesis
Best taken: With other amino acids to maintain proper ratios and prevent imbalances

Stability Considerations:

Heat Stable: Stable under normal processing temperatures (<100°C)
Light Stable: No significant photodegradation concerns
pH Sensitive: Avoid extreme pH conditions during processing
Hygroscopic: May absorb moisture - store in dry conditions

Scientific References

Reproductive Health & Nutrition: Metabolic hormones are integral regulators of female reproductive health and function - Bioscience Reports, January 2024
Clinical Safety Study: Evaluation of safe utilization of l-threonine for supplementation in healthy adults: a randomized double blind controlled trial - PMC, 2024
Dosage Guidelines: THREONINE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews - WebMD, 2024
Health Benefits Overview: Threonine: 7 Important Health Facts to Know About This Essential Amino Acid - NativePath, August 2025
Comprehensive Review: Threonine Benefits, Uses, Foods, Supplements and Side Effects - Dr. Axe, March 2023
Safety Assessment: Side Effects of Amino Acid Supplements - PMC, 2022
Chemical Profile: L-Threonine | C4H9NO3 | CID 6288 - PubChem, 2024
Medical Reference: Threonine: Health Benefits, Side Effects, Uses, Dose & Precautions - RxList, June 2021

Related Orbelli Products

Women's Hormonal Balance - Features 250mg L-Threonine for protein synthesis and reproductive tissue support
Combined with L-Lysine Hydrochloride (300mg) for synergistic essential amino acid support
Additional product links to be added

Last updated: August 2025 | This information is for educational purposes only and not intended as medical advice.