Orbelli

Complete Ingredient Profile

Ingredient Name & Common Synonyms

Primary Name: L-Lysine Hydrochloride
Common Synonyms: Lysine HCl, L-Lysine HCl, (S)-2,6-Diaminohexanoic acid hydrochloride, Lys-HCl
Chemical Classification: Essential amino acid, Basic amino acid, Hydrochloride salt form
Molecular Formula: C₆H₁₄N₂O₂ • HCl

Overview

Botanical Family: Found across multiple protein sources in the plant and animal kingdoms
Primary Origin: Animal proteins (meat, fish, dairy), legumes, quinoa, buckwheat
Extraction Method: Fermentation using Corynebacterium glutamicum or chemical synthesis, converted to hydrochloride salt for stability
Molecular Structure: Six-carbon amino acid with two amino groups, in stable hydrochloride salt form
Appearance: White, crystalline, odorless powder with a slightly bitter taste

Benefits & Uses

For Women's Hormonal Health:

Menstrual Cycle Support: Phases of the menstrual cycle affect lysine requirement in healthy women, indicating increased physiological need during certain cycle phases
Protein Synthesis: Essential for collagen production, supporting reproductive tissue health and integrity
Hormone Production: Required cofactor for the synthesis of carnitine, which supports energy metabolism crucial for hormonal balance
Reproductive Wellness: Supports overall protein metabolism needed for healthy reproductive function

Primary Health Benefits:

Tissue Growth & Repair: L-lysine is an essential amino acid for tissue growth and repair
Collagen Formation: A Critical component for collagen synthesis, supporting skin, connective tissue, and vascular health
Immune Support: Plays a role in antibody production and immune system function
Calcium Absorption: Enhances calcium absorption and may support bone health
Carnitine Synthesis: Precursor for L-carnitine production, supporting fat metabolism

Mechanism of Action:

Protein Building Block: Incorporates into proteins throughout the body
Collagen Cross-linking: Essential for hydroxylysine formation in collagen
Enzyme Cofactor: Required for various enzymatic processes
Antiviral Properties: May help suppress viral replication (particularly herpes simplex)

Safety & Warnings

General Safety Profile:

Lysine is mostly safe for most people when taken in doses up to 3000 mg daily for up to one year

Dosage Safety:

Safe Range: Up to 3000mg daily established as safe for long-term use
Orbelli Dosage: 300mg per serving - well below therapeutic limits, ensuring excellent safety
Daily Intake: Recommended daily intake of about one gram - Orbelli provides 30% of the recommended daily intake
Therapeutic Uses: Lysine supplements are often proposed for various therapeutic uses, most notably in the prevention of herpes simplex virus infections

Potential Side Effects:

Common Mild Effects: It can cause side effects such as stomach pain and diarrhea
Well-Tolerated: A daily intake of about 3 grams of lysine is generally well-tolerated
Rare Effects: Gastrointestinal discomfort, allergic reactions, kidney issues, headaches, and dizziness are some of the reported side effects

Important Warnings:

Pregnancy & Breastfeeding: Currently, there is insufficient reliable information about the safety of lysine for pregnant or breastfeeding women
Kidney Disease: There is one report of kidney disease associated with high-dose use - monitor if kidney issues exist
May cause mild throat irritation in some individuals - this is normal and typically resolves quickly
Drug Interactions: Lysine has no known serious interactions with any drugs, but consult a healthcare provider

Recommended Patch-Test Instructions:

Not applicable for oral supplements. For topical applications containing L-lysine hydrochloride, perform a 48-hour patch test on the inner forearm.

Formulation Tips

Physical Properties:

pH Range: 5.5-6.5 (slightly acidic due to hydrochloride salt)
Solubility: Highly soluble in water (>100g/100mL), sparingly soluble in ethanol
Stability: The Hydrochloride form provides enhanced stability compared to free lysine
Melting Point: 263-264°C (with decomposition)

Optimal Dosing:

Therapeutic Range: 500-3000mg daily for specific health benefits
Orbelli Formula: 300mg per serving (optimal maintenance dose for daily support)
Bioavailability: Good oral absorption, enhanced by the hydrochloride salt form
Timing: Can be taken with or without food, better absorbed on an empty stomach

Pairing Suggestions:

Synergistic with: Vitamin C (for collagen synthesis), other amino acids (threonine, methionine), zinc
Compatible with: All vitamins, minerals, and amino acids in the formulation
Enhanced by: Taking with a complete amino acid profile for optimal protein synthesis
Best taken: Between meals for maximum absorption, with adequate hydration

Stability Considerations:

Heat Stable: Stable under normal processing temperatures
Light Stable: No significant photodegradation concerns
pH Tolerance: Stable in acidic to neutral pH conditions
Moisture Sensitive: Store in dry conditions to prevent clumping

Scientific References

Women's Hormonal Needs: Phase of menstrual cycle affects lysine requirement in healthy women - American Journal of Physiology-Endocrinology and Metabolism, 2003
General Health Benefits (2025): Lysine health benefits: Evidence and food sources - Medical News Today, March 2025
Health Benefits Overview (2024): 4 Impressive Health Benefits of Lysine - Healthline, April 2024
Therapeutic Applications: Lysine as a therapeutic supplement - EBSCO Research Starters, 2024
Safety Profile: LYSINE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews - WebMD, 2024
Comprehensive Safety Assessment: Comprehensive Safety Assessment of ʟ-Lysine Supplementation from Clinical Studies: A Systematic Review - ScienceDirect, October 2020
Clinical Safety Review: Safety assessment of L-lysine oral intake: a systematic review - PubMed, 2019
Recent Benefits Review (2025): What is Lysine? Benefits and Side Effects - Vinmec, May 2025

Related Orbelli Products

Women's Hormonal Balance - Features 300mg L-Lysine Hydrochloride for protein synthesis and reproductive tissue support
Combined with other essential amino acids (L-Threonine) for a comprehensive amino acid profile
Additional product links to be added

Last updated: August 2025 | This information is for educational purposes only and not intended as medical advice.