Orbelli

Complete Ingredient Profile

Ingredient Name & Common Synonyms

Primary Name: Glutamine (L-Glutamine)
Common Synonyms: L-Glutamic acid 5-amide, 2-Aminoglutaramic acid, Glutamine amide, Q (single-letter abbreviation)
Chemical Classification: Non-essential amino acid, Conditionally essential amino acid
Molecular Formula: C₅H₁₀N₂O₃

Overview

Botanical Family: Naturally occurring in protein sources across multiple plant families
Primary Origin: Animal proteins (meat, fish, dairy), plant proteins (wheat, corn, soybeans), and synthesized endogenously in the human body
Extraction Method: Fermentation process using bacterial cultures or chemical synthesis from glutamic acid
Molecular Structure: Alpha-amino acid with an amide functional group (-CONH₂) side chain
Appearance: White, crystalline, odorless powder with mild taste

Benefits & Uses

For Women's Hormonal Health:

Gut-Hormone Connection: The gut microbiome influences the production and metabolism of hormones like estrogen, progesterone, and cortisol
Thyroid Support: If you have Hashimoto's or an underactive thyroid, consider making it a part of your hypothyroidism diet
Digestive Hormonal Impact: Low levels of gonadal circulating estrogen observed in post-menopausal women can adversely impact gut health, making gut repair crucial for hormonal balance

Primary Health Benefits:

Gut Barrier Function: L-glutamine is an essential nutrient for repairing the gut wall and helping reduce new damage. It does this by enabling enterocytes (gut cells) to regenerate more quickly, helping to seal the junctions in the gut
Digestive Support: Glutamine helps improve IBS and diarrhea by balancing mucus production. This results in healthier bowel movements
Gut Microbiome: L-glutamine may help support the gut microbiome and modulate inflammation, according to a 2021 review in Food Science and Human Wellness
Intestinal Health: Glutamine, the most abundant free amino acid in the human body, is a major substrate utilized by intestinal cells

Mechanism of Action:

Cellular Fuel: Primary energy source for intestinal epithelial cells
Barrier Protection: Maintains tight junction integrity in the gut lining
Immune Function: Glutamine is a nonessential amino acid that helps your immune and digestive systems function
Anti-inflammatory: Reduces intestinal inflammation and supports healing

Safety & Warnings

General Safety Profile:

L-glutamine supplements appear to be safe for most people, and experts say that even high doses of glutamine likely cause no harm.

Dosage Safety:

Safe Range: Supplementation of L-glutamine tends to be dosed at 5 g or above, with higher doses being advised against due to excessive ammonia in serum
Orbelli Dosage: 1000mg (1g) per serving - well below the 5g+ therapeutic range, ensuring excellent safety
Upper Limit: The lowest dose found to increase ammonia in serum has been 0.75 g/kg, or approximately 51 g for a 150 lb individual

Potential Side Effects:

Mild Digestive: Some have experienced constipation and bloating
Rare Cases: At least one case of liver toxicity has been reported with high doses
Generally Well-Tolerated: Side effects are uncommon at standard doses

Important Warnings:

Drug Interactions: They may also interfere with antiseizure medications
Pregnancy & Breastfeeding: Insufficient safety data - consult healthcare provider
May cause mild throat irritation in some individuals - this is normal and typically resolves quickly
Liver/Kidney Disease: Elderly patients are more likely to have age-related liver, kidney issues - medical supervision recommended

Recommended Patch-Test Instructions:

Not applicable for oral supplements. For topical applications containing glutamine, perform a 48-hour patch test on the inner forearm.

Formulation Tips

Physical Properties:

pH Range: 5.5-7.0 (slightly acidic to neutral in aqueous solution)
Solubility: Highly soluble in water (35.7g/100mL at 25°C), sparingly soluble in ethanol
Stability: Sensitive to heat and pH extremes, stable in dry conditions at room temperature
Melting Point: 185-186°C (with decomposition)

Optimal Dosing:

Therapeutic Range: 5-15g daily for gut health benefits
Orbelli Formula: 1000mg per serving (maintenance dose for daily gut support)
Bioavailability: Good oral absorption, rapidly utilized by intestinal cells
Timing: Can be taken with or without food

Pairing Suggestions:

Synergistic with: Prebiotics (inulin, FOS), probiotics, zinc, B-vitamins
Compatible with: Other amino acids, digestive enzymes, anti-inflammatory compounds
Enhanced by: Combining with fiber sources for comprehensive gut support
Best taken: On an empty stomach for maximum absorption, or with meals for digestive comfort

Stability Considerations:

Heat Sensitivity: Add to formulations after cooling to preserve integrity
pH Stability: Maintain neutral pH in liquid formulations
Storage: Keep in cool, dry conditions away from direct light

Scientific References

Women's Hormonal Balance & Gut Health: The Impact of Gut Health on Women's Hormonal Balance - Longdom Publishing, 2024
Gut Health Benefits for Women: A little L-glutamine can do a lot for your health - Women's Health Network, 2025
IBS and Digestive Support: L-glutamine for IBS: Benefits, side effects, and research - Medical News Today, 2024
Comprehensive Health Review: Taking L-Glutamine May Help Improve Gut Health And Immunity - Women's Health Magazine, 2024
Clinical Safety Profile: Glutamine: What It Is, Benefits & Side Effects - Cleveland Clinic, 2025
Dosage and Safety Guidelines: Glutamine benefits, dosage, and side effects - Examine.com, 2024
Intestinal Function Research: The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases - NCBI PMC, 2017

Related Orbelli Products

Women's Hormonal Balance - Features 1000mg Glutamine for gut-hormone axis support and digestive wellness
Synergistically combined with inulin and other gut-supporting ingredients
Additional product links to be added

Last updated: August 2025 | This information is for educational purposes only and not intended as medical advice.