Orbelli

Complete Ingredient Profile

Ingredient Name & Common Synonyms

Primary Name: Coenzyme Q10
Common Synonyms: CoQ10, Ubiquinone, Ubidecarenone, Vitamin Q, Q10
Chemical Classification: Benzoquinone derivative, Lipophilic antioxidant, Mitochondrial cofactor
Molecular Formula: C₅₉H₉₀O₄

Overview

Botanical Family: Synthesized endogenously in all human cells; found in organ meats and fatty fish
Primary Origin: Endogenous synthesis in mitochondria; dietary sources include heart, liver, kidney, sardines
Extraction Method: Fermentation using yeast (Saccharomyces cerevisiae) or bacterial cultures, purified through crystallization
Molecular Structure: Quinone ring with long isoprenoid side chain (10 isoprene units)
Appearance: Yellow to orange crystalline powder, lipophilic, virtually odorless

Benefits & Uses

For Women's Fertility & Reproductive Health:

Ovarian Function: Women in the CoQ10 group had an increased number of retrieved oocytes, a higher fertilization rate (67.49%), and more high-quality embryos
Diminished Ovarian Reserve: Pretreatment with CoQ10 improves ovarian response to stimulation and embryological parameters in young women with poor ovarian reserve in IVF-ICSI cycles
Egg Quality: Women who received pre-treatment of CoQ10 supplements for 60 days or longer resulted in improved egg health and higher fertilization rates
Age-Related Fertility: Because CoQ10 levels decline with age, it is often recommended as a dietary supplement for people with infertility

Primary Health Benefits:

Cellular Energy Production: Essential cofactor in the mitochondrial electron transport chain for ATP synthesis
Antioxidant Protection: Increased oxidative stress has been identified as a pathogenetic mechanism in female infertility - CoQ10 provides powerful antioxidant protection
Reproductive Vitality: Female infertility and pregnancy maintenance are associated with various factors, including the quantity and quality of oocytes
Heart Health: Supports cardiovascular function and energy metabolism

Mechanism of Action:

Mitochondrial Support: Critical component of cellular energy production
Antioxidant Activity: Neutralizes free radicals that can damage eggs and reproductive tissues
Membrane Stabilization: Protects cellular membranes from oxidative damage
Energy Enhancement: Improves cellular metabolism and vitality

Safety & Warnings

General Safety Profile:

CoQ10 appears to be safe and to produce few side effects when taken as directed

Dosage Safety:

Clinical Safety: Studies using 100-300mg daily show excellent safety profiles
Orbelli Dosage: 50mg per serving - conservative dose ensuring excellent tolerability
Fertility Studies: Most fertility studies use 100-600mg daily; your dose provides gentle daily support
Upper Limit: Doses up to 1200mg daily have been used safely in clinical studies

Potential Side Effects:

Common Mild Effects: Some people may experience mild side effects such as digestive upsets, nausea, vomiting, and diarrhea
Rare Effects: Dizziness, light sensitivity, irritability, headache, heartburn, fatigue
Drug Interactions: CoQ10 may reduce the effectiveness of the blood-thinning drug warfarin

Important Warnings:

Blood Thinners: May interact with warfarin (Coumadin) - monitor INR if taking anticoagulants
Diabetes: May affect blood sugar levels - monitor glucose if diabetic
May cause mild throat irritation in some individuals - this is normal and typically resolves quickly
Pregnancy & Breastfeeding: Generally considered safe, but consult a healthcare provider

Recommended Patch-Test Instructions:

Not applicable for oral supplements. For topical applications containing CoQ10, perform a 48-hour patch test on the inner forearm.

Formulation Tips

Physical Properties:

pH Range: Neutral to slightly acidic (6.0-7.0)
Solubility: Lipophilic - poorly water-soluble, requires a proper delivery system
Stability: Sensitive to light, heat, and oxygen - requires protective formulation
Melting Point: 48-52°C

Optimal Dosing:

Therapeutic Range: 100-600mg daily for fertility support
Orbelli Formula: 50mg per serving (optimal daily maintenance dose)
Bioavailability: Enhanced absorption when taken with fats or in powder form
Timing: Best taken with meals containing fats for optimal absorption

Pairing Suggestions:

Synergistic with: Alpha-lipoic acid, vitamin E, L-carnitine, other mitochondrial supporters
Compatible with: All antioxidants, amino acids, and fertility-supporting nutrients
Enhanced by: Taking with healthy fats for improved absorption
Best taken: With meals, consistent timing for optimal blood levels

Stability Considerations:

Light Protection: Store in opaque containers or dark conditions
Temperature Control: Keep below 25°C to prevent degradation
Oxygen Barrier: Use moisture-proof packaging with desiccants
pH Maintenance: Avoid extremely alkaline conditions

Scientific References

Latest Systematic Review (2024): Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis - Annals of Medicine, 2024
Fertility Benefits Study (2023): The Science Behind Coenzyme Q10 (CoQ10) and Its Impact on Fertility - Aspire Fertility, July 2023
Reproductive Vitality Review (2023): Coenzyme Q10 Stimulate Reproductive Vatality - PubMed, August 2023
IVF Treatment Study (2018): Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve - PubMed, March 2018
Comprehensive Meta-analysis: Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? - PMC, Systematic Review
Dosage Guidelines (2024): CoQ10 (Coenzyme Q10) Dosage - Healthline, June 2024
Safety Assessment (2024): Coenzyme Q10 benefits, dosage, and side effects - Examine.com, June 2024
Clinical Applications (2025): Coenzyme Q10 - Mayo Clinic - Mayo Clinic, May 2025

Related Orbelli Products

Women's Hormonal Balance - Features 50mg Coenzyme Q10 for cellular energy support and reproductive health
Combined with other mitochondrial supporters and antioxidants for comprehensive fertility support
Additional product links to be added

Last updated: August 2025 | This information is for educational purposes only and not intended as medical advice.